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KMID : 0606920110190030267
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Biomolecules & Therapeutics
2011 Volume.19 No. 3 p.267 ~ p.273
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Syndecan as a Messenger to Link Diabetes and Cancer
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Kim Sung-Jin
Raman OS Sethu
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Abstract
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Syndecans are membrane-anchored proteoglycans and implicated in the pathogenesis of cancer progression and metastasis. Syndecans also play important roles in interacting with growth factors, extracellular matrix and other cell surface molecules such as IGF-1 receptor. In the present review, we discuss about the syndecan structure, their role in signaling with other receptors, in addition to its general biology. The emerging roles of syndecans in the pathophysiology of human diseases, especially insulin resistance, diabetes and cancer is discussed.
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KEYWORD
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Syndecans, Insulin resistance, Diabetes and cancer
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